🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Neurobiological Mechanisms of Aging and Stress on Prospective Navigation

RecruitingNAAges 65 Years - 80 YearsAllGeorgia Institute of Technology
NCT03896529 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

Two hallmarks of both healthy aging and age-related disease are 1) memory and navigational deficits, particularly in orienting towards goal locations and planning how to navigate to them, and 2) increased susceptibility to stress and altered regulation of the stress response. However, there are marked individual differences in these age-related changes. The investigators' proposal will help characterize factors that contribute to this variability. Participants will be pseudorandomly assigned to stress-manipulated or control groups. The investigators will give both groups a novel immersive navigation task, validated by the PI in healthy young adults. This paradigm gives participants the opportunity to either (a) flexibly draw on spatial memory in order to plan efficient routes to goal locations, or (b) fall back on inefficient, but cognitively less-demanding, stimulus-response associatio

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Inclusion Criteria: * adults 65-80 * U.S. citizens or permanent residents * who speak fluent English * willing to come to Georgia Tech to participate in group testing sessions. Exclusion Criteria: * Individuals will be carefully screened using IRB-approved procedures for safety contraindications to MRI and electrical shock stimulation * (e.g., metal or electrical implants, heart arrhythmia, or medication affecting the cardiovascular system \[e.g. beta-blockers\]). The purpose of this study is to investigate mechanisms of normally functioning memory, and memory-related changes in healthy aging. Thus, any confounding factors that may influence cognition, other than age, will be exclusionary. Potential participants that endorse any of the following conditions will be excluded from the study: * Epilepsy * Dementia * Parkinson's disease * history of stroke or seizure * psychiatric disorders * untreated depression or emotional conditions * Attention Deficit Disorder * Multiple Sclerosis * uncontrolled hyper- or hypo-tension * untreated Diabetes * Sickle Cell Anemia * regularly use illegal or psychoactive drugs (e.g., cocaine, alcohol abuse, etc). * Additionally, individuals scoring \< 3 on WAIS-R forward span, \< 2 on WAIS-R backward span, and failing to name more than 2 vegetable names will be excluded from the study. These exclusions will insure that persons with mild cognitive impairment or typical indications of clinical dementia will be not participate in the research.
💊

What it tests

  • Anticipatory psychological stress
📍

Where

1 site
Center for Advance Brain Imaging
Atlanta, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy