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Three Types of Nucleotide/Nucleoside Analogues Treatment in HBV Related ACLF

RecruitingNAAges 12 Years - 65 YearsAllThird Affiliated Hospital, Sun Yat-Sen University
NCT03920618 on ClinicalTrials.gov โ†—
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In plain words

What the trial is, and whether it could suit you

This study is to investigate the clinical efficacy of three types of nucleotide/nucleoside analogues in treatment of HBV-related acute-on-chronic liver failure.

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: 1. Positive hepatitis b surface antigen or hepatitis b virus DNA \> 0.5 year; 2. Age from 12 to 65 years old; 3. Serum total bilirubin level \> 10 times upper limit of normal; 4. Prothrombin time activity \< 40% or prothrombin time international ratio \> 1.5๏ผ› 5. Do not receive nucleotide/nucleoside analogues treatment in the past half year. Exclusion Criteria: 1. Other active liver diseases; 2. Hepatocellular carcinoma or other malignancy; 3. Pregnancy or lactation; 4. Human immunodeficiency virus infection or congenital immune deficiency diseases; 5. Severe diabetes, autoimmune diseases; 6. Other important organ dysfunctions; 7. Using glucocorticoid; 8. Patients can not follow-up; 9. Investigator considering inappropriate.
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What it tests

  • Entecavir
  • Tenofovir Disoproxil Fumarate
  • Tenofovir Alafenamide
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Where

1 site
Third Affiliated Hospital of Sun Yat-sen University
Guangzhou, China
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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