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Gene Expression Changes In Young and Geriatric Skin

RecruitingEARLY Phase 1Ages 21 Years - anyAllWright State University
NCT03932162 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study does not involve any particular diagnosis. The goal of this research study is to explore the effects of artificial sunlight (ultraviolet B radiation; UVB) on the skin of young adults versus geriatric adults. Sunlight exerts many effects on the body. There is evidence that in response to ultraviolet B radiation (UVB), which are the burning rays of sunlight, young adult skin responds differently than geriatric skin. In fact, researchers feel that this difference in how the skin reacts to UVB is why skin cancers are found in older skin. Researchers believe that a major difference between young adult and geriatric skin is that young skin has a lot of a protein called insulin-like growth factor-1 (IGF-1), whereas geriatric skin has very little. The current study will test how young adult versus geriatric skin responds to UVB, and if geriatric skin treated with an injection of small

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📋 Eligibility rules (as published)
Inclusion Criteria: * Male/Female * White skin (Fitzpatrick types I and II) * Age 21-30 or 65 and older * Able to comprehend procedures/risks Exclusion Criteria: * Known photosensitivity * Currently on photosensitizing medications * Diabetes Mellitus * History of abnormal scarring * History of skin infections * Known allergy to lidocaine local anesthetic * Pregnancy or nursing * Other serious health issues
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What it tests

  • Insulin-Like Growth Factor 1
  • No Insulin-Lie Growth Factor 1
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Where

1 site
Wright State Physicians
Fairborn, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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