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โ† Trials
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Long-term Efficacy, Safety and Tolerability of Iptacopan in C3G or IC-MPGN

RecruitingPhase 3Ages 12 Years - 100 YearsAllNovartis Pharmaceuticals
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In plain words

What the trial is, and whether it could suit you

This is an open-label extension study to evaluate the long-term efficacy, safety and tolerability of iptacopan in subjects with C3 glomerulopathy or idiopathic immune-complex-membranoproliferative glomerulonephritis

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: \- Patients must have completed the treatment period of the CLNP023X2202, CLNP023B12301 or CLNP023B12302 study on study drug Exclusion Criteria: * Severe concurrent co-morbidities, e.g. advanced cardiac disease (NYHA class IV), severe pulmonary arterial hypertension (WHO class IV), or any illness or medical condition that in the opinion of the investigator and sponsor is likely to prevent the patient from safely tolerating LNP023 or complying with the requirements of the study * Participants with an active systemic bacterial, viral or fungal infection within 14 days prior to screening, or the presence of fever โ‰ฅ 38oC (100.4oF) within 7 days prior to screening. * History or current diagnosis of ECG abnormalities indicating significant risk of safety for subjects * History of HIV or any other immunodeficiency disease Other protocol-defined inclusion/exclusion criteria may apply
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What it tests

  • LNP023
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Where

53 sites
Childrens Hospital Colorado
Aurora, United States
Georgia Nephrology Research Inst
Lawrenceville, United States
University of Iowa Health Care
Iowa City, United States
University of Minnesota
Minneapolis, United States
Col Uni Med Center New York Presby
New York, United States
Novartis Investigative Site
CABA, Argentina
Novartis Investigative Site
Buenos Aires, Argentina
Novartis Investigative Site
Belo Horizonte, Brazil

โ€ฆand 45 more on ClinicalTrials.gov.

๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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