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โ† Trials
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Deciphering Mechanisms Underlying Cancer Immunogenicity

RecruitingNAAges 18 Years - anyAllInstitut Claudius Regaud
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In plain words

What the trial is, and whether it could suit you

This trial is a translational, open-label, multicentric, prospective cohort study of 1100 patients aiming to describe the PD-1 (programmed death) expression in T cells (T lymphocytes) in different solid tumors. The study will be conducted on a population of patients with local and/or metastatic malignant solid tumor and who are followed within a standard of care procedure or clinical trial. Patients with any of the following tumor types may be enrolled in the trial: * Head and neck cancer, * Ovarian cancer, * Cervical cancer, * Pre-invasive CIN III cervical cancer (Cervical Intra-epithelial Neoplasia III cervical cancer), * Other solid tumor types (including glioblastoma, NSCLC (Non-small cell lung cancer), anal cancer) Each tumor type will be considered as an independent cohort. For each included patient, biological specimen (tumor sample, blood samples and ascites samples if appli

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: 1. Patient with histologically documented local or metastatic solid malignant tumor (head and neck, ovarian, cervical, and other tumor types including, but not limited to glioblastoma, NSCLC and anal cancer) or patients with pre-invasive cervical high grade dysplasia (CIN II or III) 2. Age โ‰ฅ 18 years at the time of study entry 3. Patient followed within a standard of care procedure or clinical trial 4. ECOG Performance status 0-2 5. Patient able to participate and willing to give informed consent prior performance of any study-related procedures and to comply with the study protocol 6. Patient affiliated to a Social Health Insurance in France 7. Patient may participate to other clinical trials Exclusion Criteria: 1. Known history of positive test for Hepatitis B virus or Hepatitis C virus or Immunodeficiency Virus (HIV) or Hanta virus 2. Any condition contraindicated with blood sampling procedures required by the protocol (including Hemoglobin \< 8g/dl) 3. Patient pregnant, or breast-feeding 4. Any psychological, familial, geographic or social situation, according to the judgment of investigator, potentially preventing the provision of informed consent or compliance to study procedure 5. Patient who has forfeited his/her freedom by administrative or legal award or who is under guardianship
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What it tests

  • Blood samples, tumor biopsy specimens and ascites samples will be collected.
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Where

3 sites
Hopital Larrey
Toulouse, France
Hopital Rangueil
Toulouse, France
Institut Universitaire du Cancer Toulouse - Oncopole
Toulouse, France
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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