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Study of Viral Transduction of Human Auditory Sensory Cells for the Development of Gene Therapy

Recruitingn/aAges 18 Years - anyAllInstitut Pasteur
NCT03996824 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Gene therapy is a promising strategy to treat hearing loss and vestibular disorders, and Associated adenovirus (AAV) is shown as a good viral vector for inner ear therapy in animal models. This study aims to study in vitro viral transduction of AAV in human inner ear cells, collected during non-conservative surgeries for vestibular schwannoma.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patient ≥ 18 years old * Operative indication for a non-conservative resection of vestibular schwannoma, decided by the surgeon in accordance with the patient * Informed consent obtained * Patients with a french social protection (AME excluded) Exclusion Criteria: * Intravestibular or intra-cochlear extension of the tumor * Pregnant woman * Patient with administrative control * Medical contra-indication
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What it tests

  • Peroperative collect of inner ear cells
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Where

2 sites
Hôpital de Bicêtre
Le Kremlin-Bicêtre, France
Hôpital Pitié-Salpétrière
Paris, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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