🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Montalcino Aortic Consortium: Precision Medicine for Heritable Thoracic Aortic Disease

Recruitingn/aAges any - anyAllThe University of Texas Health Science Center, Ho…
NCT04005976 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

The Montalcino Aortic Consortium (MAC) will provide the infrastructure to assemble large cohorts of patients with mutations in known heritable thoracic aortic disease (H-TAD) genes, define the phenotype associated with these genes, and determine genetic and environmental modifiers of H-TAD.

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Inclusion Criteria: * Patients and their relatives with a confirmed pathogenic, likely pathogenic variant, or variant of unknown clinical significance in at least one of the H-TAD genes (i.e. TGFBR1, TGFBR2, SMAD3, TGFB2, TGFB3, ACTA2, MYH11, MYLK, PRKG1, MAT2A, MFAP5, LOX, COL3A1, FOXE3, and FBN1). * Patients of all ages, sex and race for which informed consent can be obtained. Exclusion Criteria: * Patients without a confirmed causative variant for H-TAD.
💊

What it tests

  • Not listed
📍

Where

20 sites
HOAG memorial hospital presbyterian
Newport Beach, United States
Hoag Memorial Hospital Presbyterian
Newport Beach, United States
Sutter Health
Sacramento, United States
University of Kentucky
Lexington, United States
Massachusetts General Hospital
Boston, United States
University of Michigan
Ann Arbor, United States
Washington University in St. Louis
St Louis, United States
University of Nebraska Medical Center
Omaha, United States

…and 12 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy