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Natural History of Hypereosinophilia and Hypereosinophilic Syndromes

Recruitingn/aAges any - anyAllUniversity Hospital, Lille
NCT04018118 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Unexplained chronic hypereosinophilia (HE) and hypereosinophilic syndromes (HES) are heterogeneous regarding the organ involvements (heart, lungs, skin, .. or none), the evolutionary profiles, the response to treatments. Underlying mechanisms are largely unknown and may associate genetic predisposing factors (germinal ? somatic?), environmental factors (alimentation, tobacco use, hormones, infections, ..) The COHESion study aims to study all clinical and biological characteristics of HE/HES patients and their evolutionary profiles, with a focus on genetic factors and the mechanisms supporting transitory or persistant chronic HE/HES (in absence of any well identified extrinsic trigger like drugs, parasitosis, ..)

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📋 Eligibility rules (as published)
Inclusion Criteria: * Men or Women of any age : * With the diagnosis criteria of hyperosinophlia OR hypereosinophilic syndrome OR specific organ eosinophilic disease according to the consensus conference of the International Cooperative Working Group on Eosinophil Disorders (ICOG-EO) * With an AEC \> 1500/mm3 or organ damage related to the presence of eosinophils in the tissues or organs whatever the context (idiopathic, clonal or reactive, including drug-related, parasitic or allergic) * HES diagnosis since 2005/01/01 * Patients socially insured * Patient who agreed to participate to the study, its proceedings and duration. Exclusion Criteria: * Known HIV infection * Not socially insured * Person unable to receive a enlighten information * Person who refuse to sign the consent * Persons deprived of their liberty * Persons benefiting from a system of legal protection (tutelage / guardianship)
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What it tests

  • Biological sample
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Where

1 site
Hôpital Roger Salengro, CHU
Lille, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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