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Optimization of Skin Preparation to Reduce Cutibacterium Acnes Colonization in Superficial and Deep Samples During Prosthetic Shoulder Surgery in Male Patients

RecruitingPhase 3Ages 18 Years - anyMaleNantes University Hospital
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In plain words

What the trial is, and whether it could suit you

Infections on joint replacements remain one of the most serious complications of orthopaedic surgery. Despite improvements in skin preparation and antibiotic prophylaxis procedures, the risk of infection of joint prosthesis is still high, particularly for shoulder prostheses, especially in men. One of the bacteria most often involved in post-operative infections for shoulder prosthesis is Cutibacterium acnes (CA). This bacterium is one of the predominant bacteria in pilosebaceous units. Eradication of this micro-organism remains difficult despite the techniques used in the preoperative phase. The objective of this protocol is to evaluate the efficacy of applying a 5% benzoyl peroxide topical during the 5 days preceding the procedure in the surgical skin incision area, which is based on local acne treatment, on the reduction of the CA bacterial load in the dermis of the approach to shoul

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📋 Eligibility rules (as published)
Inclusion Criteria: * Male patients, Adult patients, * Patient without a history of surgical intervention on the operated shoulder, * Patient managed for glenohumeral, partial (cup or anatomical hemi- arthroplasty) or total (anatomical or inverted) glenohumeral arthroplasty placement for primary osteoarthritis, or secondary to necrosis, massive rotator cuff tear or old fracture. * Patients affiliated to a social security system * Patients who have given their informed and written consent Exclusion Criteria: * Patient with arthroplasty for resumption of previous shoulder surgery or failure of arthroplasty * Patient with arthroplasty for acute trauma * Patient on immunosuppressantsimmunosuppressive drugs * Patient with inflammatory rheumatism * Patient with progressive cancer pathology * Allergies or intolerances concerning the modalities of selected skin preparations (Povidone Iodine, hypersensitivity to benzoyl peroxide) * Dermatological pathologies in the area to be treated * Acne treatment in the area to be treated within four weeks before inclusion * Patient without possible help from a third party for the application of Cutacnyl® 5% in the intervention group if necessary * Major under guardianship * Patient under the protection of justice * Patient not covered by social security
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What it tests

  • 5% benzoyl peroxide
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Where

6 sites
CHU d'Angers
Angers, France
CHU de Brest
Brest, France
CHU de Limoges
Limoges, France
CHU de Nantes
Nantes, France
CHU de Rennes
Rennes, France
CHU de Tours
Tours, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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