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Impact of Treating Severe Periodontitis on Inflammatory Activity of Atheromatous Plaques in Patients With Acute Myocardial Infarction (AMI)

RecruitingNAAges 30 Years - 70 YearsAllAssistance Publique - Hôpitaux de Paris
NCT04046237 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Multicenter randomized clinical trial with two arms in patients hospitalized for an AMI nested in the Frenchie registry. Periodontal therapy is performed by periodontists in the intervention group versus treatment by dental surgeons as part of their usual practice in the control group. For the intervention group, periodontal management will be carried out for a maximum of 6 months after randomisation, prolonged by a follow-up of 6 months including a maintenance visit at M9. All patients will have an FDG-PET at M0 and M12 for evaluation of inflammation on carotid atherosclerotic plaques.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients hospitalized for an acute myocardial infarction and included in the Frenchie registry * Score ≥ 5 on the screening questionnaire for periodontitis * Six teeth at least (excluding wisdom teeth) * Consent signature * Affiliation to a French medical insurance (Sécurité Sociale) Exclusion Criteria: * Patients with diseases,other than cardiovascular and diabetes, known to change the periodontal state such as AIDS, rheumatoid arthritis, Chediak-Higashi syndrome, Papillon-Lefèvre * Systemic antibiotic therapy\> 48 hours in the 3 months prior to inclusion * Acute heart failure * Uncontrolled ventricular rhythm disorders * Impossibility for the patient to attend follow-up visits * Impossibility to maintain the extended position for 20 minutes * Immunosuppressive therapy\> 1 month in the 6 months prior to inclusion * Pregnancy, breastfeeding * Known hypersensitivity to chlorhexidine, povidone, 18-fluoro-deoxyglucose
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What it tests

  • Periodontal treatment
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Where

1 site
Hôpital Bichat, AP-HP
Paris, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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