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Genetic Causes of Discrepant Clinic in Monogenic Twins

Recruitingn/aAges any - anyAllUniversity Hospital Tuebingen
NCT04046796 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

In the DISCO-TWIN study (prospective, open-label molecular-genetic study), twin pairs with one healthy and one affected twin with molecularly undiagnosed diseases will be analysed by means of omics technologies and/ or re-analysed using existing datasets. Phenotype and omics data will be shared within the University Hospital Tübingen and with external collaborators to improve the diagnostic rate of the subjects included in the study.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Twin pair monozygotic clinically (phenotypic) discordant twins * Unclear diagnosis * Suspected (mono-)genetic cause of the disease in one twin Exclusion Criteria: * Missing informed consent of both twin/ legal representative * No distinct phenotype
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What it tests

  • NGS Diagnostic
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Where

1 site
University Hospital Tübingen
Tübingen, Germany
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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