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Heuristics, Algorithms and Machine Learning: Evaluation & Testing in Radiation Therapy

Recruitingn/aAges 18 Years - anyAllCCTU- Cancer Theme
NCT04060706 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The Hamlet.rt study is a prospective data collection and patient questionnaire study for patients undergoing image-guided radiotherapy with curative intent. The aim of the study is to use novel machine learning and mathematical techniques to build a model that can predict the risk of significant side effects from radiotherapy treatment for an individual patient: using calculations of normal tissue dose from radiotherapy treatment planning and patient baseline characteristics derived from image and non-image data, continuously updated as the patient is reviewed both during and after treatment. A secondary goal of the project is to facilitate research in machine learning and medical image processing for radiation therapy through the creation of a discoverable and shared data resource for research use.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Participant is willing and able to give informed consent for participation in the study * Male or Female * Aged 18 years or older * Diagnosed with primary prostate cancer, head and neck cancer, lung cancer, or brain tumour * Treated with curative intent * Suitable for radical image guided radiotherapy * WHO ECOG performance status 0 or 1 * Expected survival of 18 months or more Exclusion Criteria: * Participant is not willing or able to complete the protocol-stated requirements of the study, e.g. accessing \& completing web-based long-term follow-up questionnaires.
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What it tests

  • Radical Image-Guided Radiotherapy
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Where

1 site
Cambridge University Hospitals NHS Foundation Trust
Cambridge, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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