Neurocognitive Function After Proton Therapy in Children and Adolescents

Indication: Patients with primary brain tumor Inclusion Criteria: * all groups: Patients in childhood and adolescence between 8-18 years of age * all groups: no prior radiotherapy of the brain, * all groups: The patient is able to perform repeated neuropsychological tests (approx. 1 hour per examination), * all groups: corrected visual acuity not impaired below 80% or no subjective indication of visual acuity impairment, * all groups: corrected hearing not impaired or no subjective evidence of hearing impairment, * all groups: Patient is able to perform follow-up examinations, * all groups: written consent of the patient/parent or guardian. * Brain tumour groups with/without irradiation: Primary brain tumour * brain tumor groups with/without radiation: curative or long-term palliative intention of therapy * brain tumor groups with/without irradiation: life expectancy \> 3 years * Irradiation group only: planned proton therapy with a local radiation dose of at least 40 Gy(RBE) Exclusion Criteria: * Patients under 8 or over 18 years of age (We limit the study to children over 8 years of age due to the fact that executive functions mature very late.) * Brain metastases from extracerebral tumors * Patient receives intrathecal chemotherapy * pure palliative treatment concept * The patient is not able to perform repeated neuropsychological tests (approx. 1 hour per examination). * Chronic diseases that may affect the results of neurological EEG and neuropsychological examinations. * The patient is not in a position to perform follow-up examinations * no written consent of the patient / parent or legal guardian * Participation in an intervention study whose procedures contradict those of the present study