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Correlation of Radiological Lesions With Vestibular Function in Patients With Bilateral Vestibulopathy

Recruitingn/aAges 18 Years - 90 YearsAllJessa Hospital
NCT04070937 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

In 2014 radiologic lesions were detected at one or more semicircular canals using CT and MR imaging of temporal bone in subjects carrying the p.P51S mutation in COCH. These lesions are believed to present at more advanced stages of the hearing and vestibular deterioration. Since then, other authors have described similar lesions in advanced non-genetic hearing and vestibular impairment as well. The purpose of this study is therefore to assess the radiologic investigation using CT and MR imaging of temporal bone to all subjects presenting with bilateral vestibulopathy, using the Barany criteria, compared to the p.P51S population.

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📋 Eligibility rules (as published)
Inclusion Criteria: * must meet the Barany criteria for bilateral vestibulopathy: bilaterally pathological horizontal angu- lar VOR gain \<0.6, measured by the video-HIT5 or scleral-coil technique and/or * reduced caloric response6 (sum of bither- mal max. peak SPV on each side \<6◦/sec7) and/or * reduced horizontal angular VOR gain \<0.1 upon sinusoidal stimulation on a rota- tory chair (0.1 Hz, Vmax = 50◦ /sec) and a phase lead \>68 degrees (time constant \<5 sec). * must be 18 or older Exclusion Criteria: * \< 18 y * does not meet Barany criteria for BV * contraindication for CT and MR imaging
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What it tests

  • vestibular test 1
  • vestibular test 2
  • vestibular evoked myogenic potentials
  • audiometry
  • CT and MR imaging of temporal bone
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Where

1 site
Jessa Hospital
Hasselt, Belgium
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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