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Sore Throat in Primary Care - a Comparison of Phenoxymethylpenicillin and No Antibiotic Treatment

RecruitingPhase 4Ages 15 Years - anyAllKatarina Hedin
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In plain words

What the trial is, and whether it could suit you

Sore throat is the second most common cause of antibiotic prescribing in primary care in Sweden. Guidelines for sore throat focus on identifying people with sore throat where there are 3 and 4 specified criteria and where near patient tests identify group A streptococci (GAS). In these cases, phenoxymethylpenicillin is recommended. Studies that have identified microorganisms in sore throat show that there are other bacteria and viruses than GAS, that give similar symptoms and that sometimes no microorganism is trapped despite pronounced symptoms. In recent years, a bacterium F. necrophorum has been identified, which is found in increased incidence of sore throat, but it is also found in healthy individuals. In clinical practice, many patients are treated with penicillin even if GAS is not captured. This may be because the doctor perceives the patient as sick or because other bacteria ar

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📋 Eligibility rules (as published)
Inclusion Criteria: ' Centor score 3-4: absence of cough, anamnestic fever (temperature \>38.5°C), tender cervical lymphadenitis, and tonsillar exudates (one or both tonsils) * Duration of symptoms \< 8 days * Rapid antigen detection test for GAS taken and negative * Willing and able to give informed consent. Subjects under 18 years of age must in addition have the consent from both parents/caretakers Exclusion Criteria: * Ongoing antibiotic treatment * Known or suspected allergies to phenoxymethylpenicillin * Suspicion of peritonsillar abscess or indication for admittance.
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What it tests

  • Phenoxymethylpenicillin
  • No antibiotic treatment
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Where

6 sites
Vårdcentralen Rosenhälsan
Jönköping, Sweden
Vårdcentralen Kärna
Linköping, Sweden
Vårdcentralen Lundbergsgatan
Malmö, Sweden
Mariehems hälsocentral
Umeå, Sweden
Ålidhems hälsocentral
Umeå, Sweden
Vårdcentralen Skärvet
Vaxjo, Sweden
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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