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Clinical and Immunogenetic Characterization of Giant Cell Arteritis (GCA) and Polymyalgia Rheumatica (PMR)

Recruitingn/aAges 50 Years - anyAllUniversity of Leeds
NCT04102930 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

A multi-centre observational study recruiting prospective and retrospective cohorts of patients with polymyalgia rheumatica (PMR) and giant cell arteritis (GCA). The primary aim is to find genetic determinants of GCA and PMR susceptibility, in order to yield novel insights into disease pathogenesis. A subset of the retrospective cohort is also enrolled in a post-marketing surveillance registry of patients eligible for, or receiving tocilizumab, to treat their relapsing or refractory GCA.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Willing to self-identify an ethnic group, such as Caucasian, Asian, Afro-Caribbean. * Have a firm clinical diagnosis of GCA or PMR, or (for patients identified prospectively) GCA or PMR should be more likely than any alternative explanation for the patient's symptoms. * Able and willing to give informed consent. Patients will be 50 years of age or over, unless both biopsy-proven and a clinically classical case of GCA. Exclusion Criteria: • Patient unwilling or unable to give fully informed consent.
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What it tests

  • Not listed
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Where

76 sites
Queen Elizabeth The Queen Mother Hospital
Canterbury, United Kingdom
Whiston Hospital
Prescot, United Kingdom
Nevill Hall Hospital, Aneurin Bevan University Health Board
Abergavenny, United Kingdom
Stoke Mandeville Hospital, Buckinghamshire Healthcare NHS Trust
Aylesbury, United Kingdom
Betsi Cadwaladr University Health Board
Bangor, United Kingdom
Barnsley Hospital, Barnsley Hospital NHS Foundation Trust
Barnsley, United Kingdom
Basildon University Hospital, Basildon and Thurrock University Hospitals NHS Foundation Trust
Basildon, United Kingdom
Basingstoke and North Hampshire Hospital, Hampshire Hospitals NHS Foundation Trust
Basingstoke, United Kingdom

…and 68 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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