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Pre-therapeutic MRI Assessment of Early-Stage Rectal Cancer and Significant Rectal Polyps to Avoid Major Resectional Surgery

RecruitingNAAges 16 Years - 100 YearsAllImperial College London
NCT04103372 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

When a patient is diagnosed with a rectal (bowel) polyp or cancer, radiology doctors read MRI scans to describe how deeply the cancer invades into the bowel wall (this is the 'stage' of the cancer). In this project, we will teach radiologists to find more early-stage rectal cancers. These are cancers that have only grown partially into the bowel wall. If we succeed, more patients could have these lesions removed by a local procedure that preserves the bowel and avoids the risks and complications of major surgery. We have developed a new method for radiology doctors to read MRI scans, which is more accurate than current practice. Currently only 3/10 of early rectal cancers are found by radiologists but by using our MRI reading system, 9/10 patients can be accurately identified as having early rectal cancer. We have proven that we can teach this method to other radiology doctors whose rep

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Have a rectal tumour or suspected tumour less than or equal to T3b on MRI stage or pT2 or less after excision, or 20mm or more on endoscopy with suspicion of malignancy 2. Be aged 16 years or over Exclusion Criteria: 1. Have metastatic disease at time of initial staging 2. Have a biopsy-proven rectal malignancy which is not adenocarcinoma 3. Are contraindicated for MRI
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What it tests

  • MRI scan
  • Radiologist training
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Where

23 sites
Royal Berkshire Hospital
Reading, United Kingdom
Buckinghamshire Healthcare Nhs Trust
Amersham, United Kingdom
University College London Hospitals Nhs Foundation Trust
London, United Kingdom
King'S College Hospital Nhs Foundation Trust
London, United Kingdom
West Middlesex Hospital
London, United Kingdom
Imperial College Healthcare Nhs Trus
London, United Kingdom
The Hillingdon Hospitals Nhs Foundation Trust
Uxbridge, United Kingdom
Hampshire Hospitals Nhs Foundation Trust
Basingstoke, United Kingdom

…and 15 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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