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ALFAOMEGA Master Observational Trial

Recruitingn/aAges 18 Years - anyAllIFOM ETS - The AIRC Institute of Molecular Oncolo…
NCT04120935 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

AlfaOmega has been designed to streamline the study of the co-evolutionary landscape between tumor and host cells in a cohort of CRC patients, with the aim of understanding how their outcomes can be significantly improved (e.g. reduction of their chance of recurrence and survival improval). This clinical resource for integrative clinical data and sample collection will allow the molecular story-telling of CRC metastatic spread along time and space and the selection of appropriate patients for experimentally-driven trials.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. TIER1 written Informed consent. 2. Patients ≥18 years of age. 3. Previous diagnosis of colorectal cancer, or a strong suspicion of CRC based on clinical and radiological findings. 4. In patients with previous diagnosis of CRC availability of diagnostic Formalin-Fixed, Paraffin Embedded (FFPE) blocks (surgical resection and/or tumor biopsies), or at least 10 slides (preferably 20). FFPE tissue blocks are always preferred to slides. 5. ECOG Performance status \< 2. Exclusion Criteria: 1. Any other current malignancy or malignancy diagnosed or relapsed within the past 5 years (other than non-melanomatous skin cancer, stage 0 melanoma in situ, and in situ cervical cancer) 2. Patient unable to comply with the study protocol owing to psychological, social or geographical reasons. 3. Known Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV), Hepatitis C Virus (HCV) or syphilis infection.
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What it tests

  • Observation
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Where

19 sites
ASL di Biella - Ospedale degli Infermi
Biella, Italy
IRCCS Istituto Clinico Humanitas
Milan, Italy
Fondazione IRCCS, Istituto Nazionale dei Tumori
Milan, Italy
Istituto Europeo di Oncologia (IEO)
Milan, Italy
Niguarda Cancer Center - ASST Grande Ospedale Metropolitano Niguarda
Milan, Italy
Istituto Oncologico Veneto (IOV)
Padova, Italy
Ospedale Santa Maria della Misericordia
Perugia, Italy
Azienda Ospedaliero Universitaria Pisana
Pisa, Italy

…and 11 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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