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DNA Repair Activity in the Skin of Day and Night Shift Workers

RecruitingNAAges 18 Years - 40 YearsAllWright State University
NCT04122456 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The purpose of this study is to test how the skin of night shift workers responds to artificial sunlight (ultraviolet B radiation; UVB) at two different times of the day in comparison to normal day shift workers. After the skin biopsies are obtained, they will be brought to the laboratory to be exposed to UVB radiation and to measure UVB responses.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Male/Female * Fair skin (Fitzpatrick types I and II) * Age 18 to 40 * Able to comprehend procedures/risks * Primarily work and are awake during normal daylight hours (6 am to 6 pm), or primarily work and are awake during night shifts hours (between the hours of 6 pm and 6 am) or may work a mixture of these shifts over the past 3 months. Rotating shifts will be categorized based on the majority of hours worked on average during the last 3 months. Able to fill out a 3-month calendar of work schedule. Exclusion Criteria: * Known photosensitivity * Currently on photosensitizing medications * Diabetes Mellitus * On any hormonal agents (e.g., birth control pills) * History of abnormal scarring * History of skin infections * History of skin cancers * History of sleep disorders such as sleep apnea or insomnia * Known allergy to lidocaine local anesthetic * Pregnancy or nursing * Other serious health issues
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What it tests

  • Ultraviolet B Radiation
  • No Ultraviolet B Radiation
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Where

1 site
Wright State Physicians
Fairborn, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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