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Personalized Swiss Sepsis Study

Recruitingn/aAges 18 Years - anyAllUniversity Hospital, Basel, Switzerland
NCT04130789 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This multi-center study is to focus on patients with sepsis in Intensive Care Units (ICUs) in order to better understand the complex host-pathogen interaction and clinical heterogeneity associated with sepsis. Understanding this heterogeneity may allow the development of novel diagnostic approaches. Data from patients will be analyzed using state-of-the art analytical algorithms for biomarker discovery including machine learning and multidimensional mathematical modelling to explore the large datasets generated. In order to discover digital biomarkers for the study endpoints a case-control study design will be used to compare data patterns from patients with sepsis (cases) and those without sepsis (controls).

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients admitted to an ICU on a Swiss University Hospital. * Patients expected to stay at least 24h on the ICU Inclusion Criteria (cases) * Present at admission to ICU or subsequent development of sepsis 3.0 criteria Inclusion Criteria (controls) * Patients not fulfilling sepsis definition during the ICU stay Exclusion Criteria: * Decline of general consent or any other negative statement against using data for research. * Patients with a clear elective stay on the ICUs.
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What it tests

  • compare data patterns by data-driven algorithms to determine sepsis
  • compare data patterns by data-driven algorithms to predict sepsis-related mortality
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Where

16 sites
Clinical Microbiology, University Hospital Basel
Basel, Switzerland
Infectious Diseases and Hospital Epidemiology, University Hospital Basel
Basel, Switzerland
Medical Intensive Care Unit; University Hospital Basel
Basel, Switzerland
Surgical Intensive Care Unit, University Hospital Basel
Basel, Switzerland
Institute for Infectious Diseases, University of Bern
Bern, Switzerland
Division Infectious Diseases, University Hospital Bern
Bern, Switzerland
Intensive Care Medicine, University Hospital Bern
Bern, Switzerland
Division Bacteriology Laboratory, University Hospital Geneva
Geneva, Switzerland

…and 8 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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