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โ† Trials
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Albumin-bound Paclitaxel and Carboplatin Versus Epirubicin and Docetaxel for Triple-negative Breast Cancer

RecruitingPhase 4Ages 18 Years - 70 YearsFemaleShengjing Hospital
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In plain words

What the trial is, and whether it could suit you

To investigate the efficacy of albumin-bound paclitaxel combined with carboplatin versus epirubicin combined with docetaxel as neoadjuvant therapy for triple-negative breast cancer.

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * patients developing breast cancer as confirmed by X-ray examination, cancer tissue negative for estrogen receptor, progesterone receptor and HER2, and tumor stage II-III; * estimated survival \> 3 months; * presence of clinically measurable lesions; * Karnofsky functional status score โ‰ฅ 70; * normal routine blood test results, normal liver and kidney function, and near normal electrocardiographic manifestations; * age at 18-70 years. Exclusion Criteria: * stage IV breast cancer patients with bone metastasis or other distant metastasis; * severe renal insufficiency; * older adult patients with severe organic diseases such as heart and lung diseases, who are not estimated to be able to tolerate chemotherapy; * those who have received antineoplastic therapy; * those who have received neoadjuvant chemotherapy but fail in 2 cycles of neoadjuvant chemotherapy and switch to other regimens or terminate chemotherapy; * those with history of other malignant tumors; * those with severe heart, liver, and kidney organ dysfunction or poor health who cannot tolerate chemotherapy, or those who cannot tolerate chemotherapy and switch to other therapeutic regimens; * those with mental and nervous system diseases who cannot comply with treatment; * those with dexamethasone intolerance or those who are highly allergic to any drug in neoadjuvant chemotherapy; * pregnant or lactating women; * those who are participating in other trials.
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What it tests

  • Albumin-bound paclitaxel combined with carboplatin
  • Epirubicin combined with docetaxel
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Where

7 sites
Cancer Hospital Affiliated to Harbin Medical University
Harbin, China
The Second Hospital of Jilin University
Changchun, China
Dalian Municipal Central Hospital
Dalian, China
Panjin Liaohe Oilfield Gem Flower Hospital
Panjin, China
Shengjing Hospital of China Medical University
Shenyang, China
The Fourth Affiliated Hospital of China Medical University
Shenyang, China
Liaoning Cancer Hospital & Institute
Shenyang, China
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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