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Transcranial Direct Current Stimulation (tDCS) With Verb Network Strengthening Treatment (VNeST) in Chronic Aphasia

RecruitingNAAges 21 Years - 80 YearsAllCity University of New York
NCT04142866 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The purpose of this study is to assess changes in language abilities of participants with chronic, post-stroke aphasia following an 8-week therapy period combined with brain stimulation. The investigators use a stimulation method called transcranial direct current stimulation (tDCS). The investigators cover two electrodes in damp sponges, place them on the scalp, and pass a weak electrical current between them. Some of this current passes through the brain and can change brain activity. One electrode is placed over language areas a bit above and in front of the left ear. The other is placed on the forehead above the right eye. Stimulation is provided twice a week for 8 weeks during aphasia therapy. The investigators believe that this stimulation may increase the effectiveness of therapy.

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📋 Eligibility rules (as published)
This study recruits individuals with post-stroke aphasia as well as a group of healthy volunteers matched for age, sex, and education. INCLUSION Criteria: * Right handed (pre-stroke for participants with aphasia) * High school education or equivalent * Native English fluency without early 2nd language exposure (before age 10) * Ability to perform the required discourse and MRI tasks (determined via in-person screening) Additional INCLUSION Criteria for participants with APHASIA: * Single-event left hemisphere stroke \> 6 months prior to enrollment * Aphasia diagnosis per Western Aphasia Battery-Revised * Not receiving any other speech therapy for the entire study period (20 weeks) * Ability to perform the required therapy tasks (determined via in-person screening) EXCLUSION Criteria: * Failed vision or hearing screening * MRI contraindications (including pacemaker) * Pregnancy * History of seizure or change in seizure medication in past 12 months * History of speech/language, psychiatric, or neurological disorder, or current serious medical condition (except chronic stroke comorbidities for participants with aphasia) Additional EXCLUSION criteria for participants with APHASIA are: * Unmodifiable hair style precluding scalp contact by electrodes * Sensitive scalp by self-report
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What it tests

  • Anodal transcranial direct current stimulation
  • Sham transcranial direct current stimulation
  • Speech-Language Therapy (SLT)
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Where

1 site
City University of New York
New York, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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