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Idebenone for the Preventive Treatment of Migraine

RecruitingPhase 3Ages 18 Years - 65 YearsAllSecond Affiliated Hospital, Zhejiang University, …
NCT04151472 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Idebenone improves energy metabolism similarly to Coenzyme Q10, which is effective in migraine prophylaxis. The investigators compare idebenone (90 mg/day, 270 mg/day) and placebo in 180 migraine patients in a double-blind, randomized, placebo-controlled, multicenter trial to study whether Idebenone is superior to placebo in the prevention of episodic migraine with or without aura.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Clinical diagnosis of episodic migraine. 2. Patients (18-65 years) were eligible if they met International Headache Society (IHS) criteria for episodic migraine with/ without aura with a migraine history 1 year 3. Two to eight attacks per month, 5 days/month of interval headaches. 4. No over consumption of acute anti-migraine medication. 5. No other prophylactic medication (washout 3 months). 6. No serious organic or psychiatric disease. 7. Only women with contraceptive protection. Exclusion Criteria: 1. Clinical diagnosis of chronic migraine. 2. Subjects previously discontinued idebenone due to adverse events. 3. Subjects are taking idebenone or had taken idebenone within 14 days prior to enrollment. 4. Subjects with continuous headaches.
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What it tests

  • Placebo
  • 90mg Idebenone
  • 270mg Idebenone
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Where

1 site
Kaiming Liu
Hangzhou, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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