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Cerebral Oxygen Metabolism in Children

RecruitingNAAges 3 Years - 50 YearsAllWashington University School of Medicine
NCT04157179 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The purpose of this research study is to better understand how blood flow and metabolism change can influence brain development in the early decades of life. We will examine brain blood flow and metabolism using magnetic resonance imaging (MRI). The brain's blood vessels expand and constrict to regulate blood flow based on the brain's needs. The amount of expanding and contracting the blood vessels can do varies by age. The brain's blood flow changes in small ways during everyday activities, such as normal brain growth, exercise, or deep concentration. Significant illness or psychological stress may increase the brain's metabolic demand or cause other bigger changes in blood flow. If blood vessels are not able to expand to give more blood flow when metabolic demand is high, the brain may not get all of the oxygen it needs. In extreme circumstances, if the brain is unable to get enough o

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📋 Eligibility rules (as published)
Healthy Controls: * Healthy controls ages 3-50 years of age * Able to participate in MRI scan without sedation * Not currently pregnant * No significant psychiatric history, defined as having a severe psychiatric diagnosis, per PI discretion * No history of epilepsy * No history of stroke or cerebrovascular disease * May have occasional headaches if not taking a daily preventative medication for headaches * Not on vasodilatory medication, such as sildenafil or verapamil Sickle Cell Anemia Participants: * Ages 3-50 years of age * Hb SS or SBeta-thal * Able to participate in MRI scan without sedation * Not currently pregnant * Not on vasodilatory medication, such as sildenafil or verapamil Extracorporeal Membrane Oxygenation (ECMO) Survivors: * Ages 3-50 years of age * History of cannulation for ECMO * Able to participate in MRI scan without sedation * Not currently pregnant * Not on vasodilatory medication, such as sildenafil or verapamil
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What it tests

  • Carbon Dioxide
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Where

1 site
Washington University of St. Louis
St Louis, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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