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Operative Versus Non-Operative Management for Appendicitis With Abscess or Phlegmon

RecruitingNAAges 18 Years - anyAllYale University
NCT04168866 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The investigators aim to determine if early operative intervention is superior to non-operative management for adult patients with computerized tomography (CT)-proven complicated appendicitis with phlegmon or abscess.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1\. Complicated appendicitis with presumed perforation on (computer tomography) CT scan AND phlegmon or abscess greater than 2 centimeter (cm). Exclusion Criteria: 1. Antibiotic therapy greater than 24 hours prior to considering for enrollment. 2. Attempted drainage before randomization 3. Pregnancy 4. Antibiotic allergy requiring the use of something other than a beta-lactam or quinolone based therapy. 5. Previous major intra-abdominal surgery by laparotomy 6. Hospitalization within 2 weeks of randomization 7. Presence of septic shock on admission. 8. Mechanical ventilation 9. Acute renal failure requiring dialysis
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What it tests

  • Operative management
  • Drainage or antibiotics
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Where

1 site
Yale New Haven Hospital
New Haven, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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