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Treatment of Breakpoint Cluster Region-Abelson (BCR-ABL) Negative ALL in Adults

RecruitingNAAges 18 Years - 60 YearsAllPETHEMA Foundation
NCT04179929 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

After consolidation therapy adult patients (≥18 yr) with Ph-negative ALL will be treated with continuation chemotherapy or allogeneic hematopoietic stem cell transplantation (alloHSCT) according to both measurable residual disease (MRD) and results of genetic study performed at baseline.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients 18-60 yr with de novo Ph-neg ALL * Eastern Cooperative Oncology Group (ECOG) 0-2 (or \>2 if due to ALL) * Informed consent Exclusion Criteria: * Mature B-ALL, Ph+ ALL or blast crisis of chronic myeloid leukemia (CML), ALL of ambiguous lineage * ECOG \>2 not due to ALL * Impaired cardiac, respiratory, hepatic or renal function not due to ALL * Pregnancy * HIV positivity * Severe psychiatric disease * Negative to sign informed consent.
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What it tests

  • Pediatric-type of chemotherapy
  • allogeneic HSCT
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Where

108 sites
Ico-Hugtip
Badalona, Spain
H. A Coruña
A Coruña, Spain
H Albacete
Albacete, Spain
H. General Univ. de Alicante
Alicante, Spain
H. General Univ. de Alicante
Alicante, Spain
Hospital Nuestra Señora de Sonsoles
Ávila, Spain
Clínica Teknon
Barcelona, Spain
H del Mar
Barcelona, Spain

…and 100 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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