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Controlled Fluid Removal in Critical Ill Patients With Fluid Overload in the Intensive Care Unit.

RecruitingPhase 4Ages 18 Years - anyAllMorten H. Bestle
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In plain words

What the trial is, and whether it could suit you

This study evaluates the benefits and harms of goal directed fluid removal with furosemide versus placebo in critical ill adult patients with fluid overload in the intensive care unit. Half of the patients will receive furosemide and the other half placebo. The treatment will continue until the excess fluid is excreted.

Sign in to get the eligibility rules as simple questions to take to your doctor.

📋 Eligibility rules (as published)
Inclusion Criteria: ALL below must be met. * Acute admission to the intensive care unit. * Age ≥ 18 years of age * Fluid overload ≥ 5% of ideal body weight. If possible, all fluids administered before admission to the intensive care unit are to be included in the calculation of cumulative fluid balance. * Clinical stable (minimum criteria: MAP \> 50 mmHg and maximum infusion of 20 microgram/kg/minute of noradrenaline and lactate \< 4.0 mmol/L) Exclusion Criteria: * Known allergy to furosemide or sulphonamides. * Known pre-hospitalization advanced chronic kidney disease (eGFR \< 30 mL/minute/1.73 m\^2 or chronic RRT). * Ongoing renal replacement therapy. * Anuria \> 6 hours. * Rhabdomyolysis with indication for forced diuresis * Ongoing life-threatening bleeding as these patients need specific fluid/blood product strategies. * Acute burn injury of more than 10% of the body surface area as these patients need a specific fluid strategy. * Severe dysnatremia (p-Na \< 120 or \> 155 mmol/L) as these patients need a specific fluid strategy. * Severe hepatic failure as per the clinical team. * Patients undergoing forced treatment. * Fertile women (women \< 50 years) with positive urine human chorionic gonadotropin (hCG) or plasma-hCG. * Consent not obtainable as per the model approved for the specific trial site.
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What it tests

  • Furosemide
  • Isotonic saline
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Where

29 sites
Department of Intensive Care, Liverpool Hospital
Sydney, Australia
Department of Intensive Care, Royal North Shore Hospital
Sydney, Australia
Department of Intensive Care, University Hospital of Ostrava
Ostrava, Czechia
Department of Intensive Care, University Hospital of Pilsen
Pilsen, Czechia
Department of Intensive Care, IKEM
Prague, Czechia
Department of Intensive Care, Sygehus Sønderjylland Aabenraa
Aabenraa, Denmark
Departmen of Intensive Care
Aalborg, Denmark
Department of Intensive Care, Aarhus University Hospital
Aarhus, Denmark

…and 21 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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