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Imaging Post-Stroke Recovery: Using MEG to Evaluate Cognition

Recruitingn/aAges 18 Years - 100 YearsAllJohns Hopkins University
NCT04188522 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This is a study using magnetoencephalography (MEG) to look at recovery in those with minor stroke. The investigators know that these individuals report difficulties in attention, concentration, multi-tasking, energy level, and processing speed that appear to be independent of lesion size or location. The underlying pathophysiology is unclear; however, anecdotally, many individuals are significantly improved by 6 months post-stroke. One hypothesis is that a single lesion, regardless of size, may disrupt the classic neural networks required for cognitive function. The investigators are currently collecting data to better characterize these difficulties and stroke patients' recovery as part of a previously approved recovery study. In this sub-study, the investigators propose to add MEG at 1 and 6 months in a subset of individuals with small: 1) subcortical, and 2) cortical lesions. The inve

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Adults (≥18 years) admitted to Bayview Medical Center Neurology. 2. Evidence of acute ischemic stroke (CT or MRI)- lacunar stroke or branch occlusion (M3/A3/P3 or smaller) OR NIHSS ≤ 8 on admission. 3. Competent speaker of English (by self or family report) prior to stroke. 4. Return for follow-up 4-6 weeks post event (+/- 4 wks). 5. Cognitive deficits present on initial testing.\*\* unique to MEG study 6. Willing to travel to the University of Maryland twice for MEG.\*\* unique to MEG study 7. Fully independent functionally and able to travel to the University of Maryland unassisted.\*\* unique to MEG study Exclusion Criteria: 1. Primary intracerebral hemorrhage- as evidenced by blood on head CT or MRI. 2. Previous neurological disease (e.g., dementia, multiple sclerosis, prior symptomatic stroke). Incidental asymptomatic lacunar strokes found on imaging will not be excluded as prior disease. 3. Uncorrected hearing or visual loss. 4. Large vessel occlusion. 5. Presence of any of the following that would lead to significant artifact on MEG: cardiac pacemaker, intracranial clips, metal implants, or external clips within 10mm of the head, metal in the eyes.\*\* unique to MEG study 6. Claustrophobia, obesity, and/or any other reason leading to difficulty staying in the MEG for up to 1 hour.\*\* unique to MEG study 7. For controls- clinical history of stroke or other neurological dysfunction (seizure, multiple sclerosis, etc.); psychiatric disease
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What it tests

  • Magnetoencephalography (MEG)
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Where

1 site
Johns Hopkins Bayview Medical Center
Baltimore, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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