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Safe Threshold to Discontinue Phototherapy in Hemolytic Disease of Newborn

RecruitingNAAges 1 Hour - 14 DaysAllMinistry of Health, Saudi Arabia
NCT04218318 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

We hypothesized that adopting a lower rather than a higher threshold for phototherapy discontinuation will be associated with reduced rates of rebound hyperbilirubinemia in term and late preterm neonates with hemolytic disease of newborn. Objectives: The investigators aimed to compare the safety of implementing low-threshold, compared to high- threshold, of TSB for phototherapy interruption in term and late preterm neonates with hemolytic disease of newborn.

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📋 Eligibility rules (as published)
Inclusion Criteria: Healthy term and late-preterm neonates more than or equal 35 weeks gestation with hemolytic disease of newborn will be included. Enrolled infants should have evidence of hemolysis as defined by any of the following criteria: 1. positive DAT and blood group iso-immunization (ABO / RH incompatibility);and /or 2. HGB decline by 2g/dl within 24hour. Exclusion Criteria: * Major congenital abnormalities, * Surgical problems, * Direct hyperbilirubinemia * Sepsis
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What it tests

  • phototherapy
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Where

1 site
Madinah maternity and children's hospital
Madinah, Saudi Arabia
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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