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Early Use of Airway Pressure Release Ventilation (APRV) in ARDS

RecruitingNAAges 18 Years - 80 YearsAllHospital Civil de Guadalajara
NCT04221737 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Airway pressure release ventilation (APRV) is a time-cycled, pressure controlled, intermittent mandatory ventilation mode with extreme inverse I:E ratios. Currently it is considered as a non-conventional ventilatory mode. The investigators aim to compare APRV with conventional mechanical ventilation (MV) in patients with acute respiratory distress syndrome (ARDS).

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📋 Eligibility rules (as published)
Inclusion Criteria: * Acute respiratory distress syndrome, according to the Berlin definition of ARDS, with adjusted pO2/FiO2 for altitude \<300, and less than 48 h of endotracheal mechanical ventilation Exclusion Criteria: * Pregnancy * Less than 18 years-old * Expected duration of mechanical ventilation less than 48 h * Preexisting conditions with an expected 3-month mortality exceeding 50% * Concurrent chemotherapy * Confirmed intracranial hypertension * Catastrophic cranial trauma or neuromuscular disorders that are known to prolong mechanical ventilation * Pneumothorax at enrollment (resolved or not) * Do-not-resuscitate order
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What it tests

  • APRV. General Electric Healthcare Engstrom ventilator system
  • Conventional. General Electric Healthcare Engstrom ventilator system
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Where

1 site
Hospital Civil Fray Antonio Alcalde
Guadalajara, Mexico
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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