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Perioperative Respiratory Care and Outcomes for Patients Undergoing High Risk Abdominal Surgery

RecruitingPhase 3Ages 10 Years - 100 YearsAllUniversity of Birmingham
NCT04256798 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

PENGUIN is a pragmatic multi-center trial investigating the effects of pre-operative mouthwash and perioperative oxygen on the incidences of pneumonia and surgical site infection (SSI) following major abdominal surgery. Patients will be recruited from low and middle income countries and randomly assigned to a trial treatment arms: a) pre-operative chlorhexidine mouthwash and 80-100% FiO2; b) no pre-operative mouthwash and 80-100% fraction of inspired oxygen (FiO2); c) pre-operative chlorhexidine mouthwash and 21- 30% FiO2; or d) no pre-operative mouthwash and 21-30% FiO2.

Sign in to get the eligibility rules as simple questions to take to your doctor.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adults and children aged 10 years or over * Elective or emergency abdominal surgery via midline laparotomy with an anticipated abdominal incision of at least 5cm in length * Written informed consent of patient (signature or a fingerprint) Exclusion Criteria: * Patients undergoing caesarean section * Patients with a documented or suspected allergy to chlorhexidine * Patient unable to complete postoperative follow-up (not contactable after discharge) * Previous enrolment in PENGUIN within the past 30 days * American Society of Anesthesiologists (ASA) grade V patients (expected to die with or without surgery)
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What it tests

  • Chlorhexidine mouthwash
  • Oxygen
  • Oxygen
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Where

37 sites
Hospital das Clinicas da Faculdade de Medicina de Botucatu - UNESP
Botucatu, Brazil
Hospital de Clinicas de Porto Alegre
Porto Alegre, Brazil
Hospital Nossa Senhora da Conceicao
Porto Alegre, Brazil
Hospital Universitario Professor Edgar Santos/Bahia
Salvador, Brazil
Hospital Sao Jose - Criciuma/SC
São José, Brazil
Homi Bhabha Cancer Hospital & Research Centre
Visakhapatnam, India
Sher - i - Kashmir Institute of Medical Sciences
Srinagar, India
Chinchpada Christian Hospital
Chinchpāda, India

…and 29 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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