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Tessa Jowell BRAIN MATRIX - Platform Study

Recruitingn/aAges 16 Years - anyAllUniversity of Birmingham
NCT04274283 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The main aim of the Tessa Jowell BRAIN MATRIX - Platform Study is to more precisely determine the exact type of tumour patients have by developing the essential infrastructure to provide rapid and accurate molecular diagnosis. A large network of clinical hubs across the United Kingdom, with expertise in managing patients with brain tumours, will be developed. Once established this infrastructure will facilitate the rapid introduction of clinical trials testing targeted therapies tailored to the genetic changes of an individual's tumour.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Newly diagnosed suspected WHO Grade 2-4 glioma, (as evidenced radiologically) AND suitable for a diagnostic or therapeutic surgical procedure resulting in a tumour sample matched to a blood sample. * Patients with progression with known WHO Grade 2-4 glioma (those with available frozen tumour will be prioritised for detailed genomic analysis). * Valid written informed consent for the study. Exclusion Criteria: * Primary spinal cord tumours * Active treatment of other malignancy * Contraindication to MRI * Patients without standard of care imaging available
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What it tests

  • Matched Tumour and Blood Sample - Research Pathway
  • Matched Tumour and Blood Sample - NHS GMS pathway
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Where

14 sites
Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust
Birmingham, United Kingdom
Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust
Cambridge, United Kingdom
Velindre Cancer Centre, Velindre University NHS Trust
Cardiff, United Kingdom
NHS Lothian
Edinburgh, United Kingdom
Queen Elizabeth Unviersity Hospital, NHS Greater Glasgow and Clyde Health Board
Glasgow, United Kingdom
St James's University Hospital, Leeds Teaching Hospitals NHS Trust
Leeds, United Kingdom
The Walton Centre, The Walton Centre NHS Foundation Trust
Liverpool, United Kingdom
King's College Hospital, King's College Hospital NHS Foundation Trust
London, United Kingdom

…and 6 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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