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Combined Nerve and Tendon Transfer for the Restoration of Hand Function in Individuals With Tetraplegia

Recruitingn/aAges 15 Years - 55 YearsAllGöteborg University
NCT04276181 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Tetraplegia after a cervical spinal cord injury (C-SCI) radically alters an individual's ability to perform normal activities of daily life due to paralysis in all extremities, resulting in lifelong dependence.\[1\] Traditional tendon transfer surgery has proven successful in restoring grip functions which greatly improves autonomy, but with a restricted passive opening of the hand. The number of transferrable muscles in the arm is however limited, why nerve transfer surgery is a new attractive option to further improve hand function by enabling active opening of the hand. Significant advantages of distal nerve transfers include less extensive surgical dissection, greatly reduced hospital stay, rehabilitation and restrictions, and thereby less health care use and costs. In an effort to further improve hand function and independence in patients with tetraplegia, hand surgeons at Centre fo

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📋 Eligibility rules (as published)
Inclusion criteria: * Subjects must be between 15-55 years of age * Subjects must be diagnosed with a spinal cord injury AIS level C5 to C7 * Time after injury ≤ 12 months * The strength of the muscle supplied by the donor nerve (supinator) must be graded ≥ 4 according to Medical Research Council (MRC) * The strength of musculus brachioradialis and wrist extensors must be graded ≥ 4 according to MRC (to be used in grip reconstruction) Exclusion criteria: * Finger extensor strength ≤ MRC 1 * Evidence of lower motor neuron injury in muscles supplied by the donor nerve * Subjects must not have any current serious or unstable illness that could interfere with the study * Medically unstable to undergo surgery as determined by physician * Spasticity in the forearm or hand graded \> 1 according to Modified Ashworth Scale
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What it tests

  • Not listed
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Where

1 site
Center for Advanced Reconstruction of Extremities, Sahlgrenska University Hospital/Mölndal
Mölndal, Sweden
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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