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TUBectomy With Delayed Oophorectomy in High Risk Women to Assess the Safety of Prevention

RecruitingNAAges 25 Years - 50 YearsFemaleUniversity Medical Center Nijmegen
NCT04294927 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The aim of the project is to evaluate the risk-reducing salpingectomy with delayed oophorectomy as an alternative for risk-reducing salpingo-oophorectomy in high risk women with respect to ovarian cancer incidence.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Women with a class 5 (definitely pathogenic) BRCA1, BRCA2, RAD51C, RAD51D or BRIP1 germline mutation in one of the participating centers. * Age at inclusion; * BRCA1: 25-40 years * BRCA2: 25-45 years * RAD51C, RAD51D, BRIP1: 25-50 years * Childbearing completed * Presence of at least one fallopian tube * Participants may have a personal history of non-ovarian malignancy * Informed consent must be obtained and documented according to national and local regulatory requirements and the local rules followed in the institution. Exclusion Criteria: * Postmenopausal status (natural menopause or due to treatment) * Wish for second stage RRO within two years after RRS * Legally incapable * Prior bilateral salpingectomy * A personal history of ovarian, fallopian tube or peritoneal cancer * Current diagnosis or treatment for malignant disease
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What it tests

  • Risk-reducing salpingectomy with delayed oophorectomy
  • Risk-reducing salpingo-oophorectomy
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Where

66 sites
UChicago Medicine
Chicago, United States
Dana Farber Cancer Institute
Boston, United States
Mayo Clinic
Rochester, United States
Washington University Medical Center
St Louis, United States
Mount Sinai Hospital
New York, United States
Memorial Sloan Kettering Cancer Center
New York, United States
Duke University Hospital
Durham, United States
Hospital of the University of Pennsylvania
Philadelphia, United States

…and 58 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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