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Effects of Drinking Beetroot Juice on Exercise Performance in Patients With Fibrotic Interstitial Lung Disease

RecruitingNAAges 19 Years - anyAllUniversity of British Columbia
NCT04299945 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Exercise training as part of a structured pulmonary rehabilitation program is a key factor in improving quality of life and symptoms in people with interstitial lung disease (ILD). Optimal methods of exercise training are yet to be explored in ILD. Drinking beetroot juice, which is rich in nitrate, has been shown to improve exercise performance in a variety of groups, but its effects in ILD have not been tested. The purpose of this study is to determine if drinking nitrate-rich beetroot juice can improve exercise performance compared to drinking nitrate-free beetroot juice in people with ILD.

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📋 Eligibility rules (as published)
Inclusion Criteria: * A multidisciplinary diagnosis of idiopathic pulmonary fibrosis (IPF), idiopathic fibrotic nonspecific interstitial pneumonia (NSIP), chronic hypersensitivity pneumonitis (HP), or unclassifiable ILD with a differential diagnosis that consists of the above diagnoses * Fibrosis on high resolution computed tomography (HRCT): honeycombing, reticulation, or traction bronchiectasis * Oxygen saturation ≥92% by pulse oximetry at rest while breathing room air * Clinically stable for the preceding 6 weeks * Can fluently read and write in English Exclusion Criteria: * Contraindication to exercise testing (e.g. significant cardiovascular, musculoskeletal, neurological disease) (see Table 4 from ERS/ATS consensus statement) * Other significant pulmonary or extra-pulmonary disease that, based on clinical assessment, could impair exercise capacity and/or oxygenation * FVC \<50% or DLCO \<25% * Use of prednisone \>10 mg/day for \>2 weeks within 3 months of the first study visit * Cardiac pacemaker or any metal or electronics inside of the body
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What it tests

  • concentrated beetroot juice (400mg of nitrate per serving)
  • concentrated beetroot juice (trace amounts of nitrate per serving)
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Where

2 sites
Providence Health Care - St. Paul's Hosptial
Vancouver, Canada
Vancouver Coastal Health
Vancouver, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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