Origin and Function of Eosinophilic Polynuclear During DRESS Syndrome

Inclusion Criteria: Group 1 (DRESS): adult with a diagnosis of DRESS based on the following four criteria: * Cutaneous rash occurring at least 24 hours and at most 2 months after continuous medication use * Fever over 38 degre celcius * At least one organ dysfunction among: * Lymphadenopathy * hepatitis * Pulmonary involvement * Cardiac involvement: myocarditis, pericarditis * Renal impairment * At least one of the following hematological anomalies: * Eosinophilia ≥ 500 / mm3 . * RegiSCAR Score ≥ 4 Groups 2 and 3 (Drug induced maculopapular exanthema without or with eosinophilia). * Adult with drug-induced rash * Without clinical criteria of severity defined by Djien among : * An evolution of more than 21 days * with organ damage as defined in group 1 Group 2 (MPE without eosinophilia): blood eosinophils \< 500 / mm3 Group 3 (MPE with eosinophilia): blood eosinophils ≥ 500 / mm3 Exclusion Criteria: * Other cause of eosinophilia including cancer, blood disease before the introduction of suspected molecule(s). * On going oral or local corticosteroid therapy, anti-leukotriene therapy (MONTELUKAST) by the month preceding the study; * Anti-IgE therapy (OMALIZUMAB, LIGELIZUMAB), anti-IL-5 therapy (MEPOLIZUMAB, BENRALIZUMAB) or anti-IL4 and / or anti-IL13 therapy (DUPILUMAB, TRALOKINUMAB) in the 6 months preceding the study. * Any pregnant or lactating woman. * Contraindication related to the blood volume taken for the study.