AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Prospective Multicenter Randomized Comparative Study of the Treatment of de Novo Stenosis in Chron's Disease.

RecruitingNAAges 18 Years - 80 YearsAllGrupo Espanol de Trabajo en Enfermedad de Crohn y…
💬

In plain words

What the trial is, and whether it could suit you

Stenosis is one of the most frequent complications in patients with Crohn's disease (CD), causing greater morbidity and increasing the probability of repeated surgery and short bowel syndrome (1-3). Endoscopic balloon dilation (EBD) is clearly the treatment of choice for short stenoses located at the anastomosis of previous surgeries (4-6). However, there is no scientific evidence for determining the most appropriate treatment for de novo stenosis less than 10 cm in length (surgical versus endoscopic treatment), both in terms of efficacy and complications. Neither has it been established which of these two approaches has a greater impact on the quality of life of patients and on costs.

Sign in to get the eligibility rules as simple questions to take to your doctor.

📋 Eligibility rules (as published)
Inclusion Criteria: * 18-80 years of age. * Crohn's disease with predominantly de novo fibrotic stenosis\* confirmed by endoscopic and radiological tests, accessible by endoscopy (colonoscopy). * Patients with known stenosis previously treated with stenting and/or dilation performed over one year before the date of inclusion. * Symptomatology of intestinal occlusion-subocclusion. * Refractoriness to conventional medical treatment (non-response to the usual accelerated step-up therapeutic approach). * Stenosis length \< 10 cm. * Maximum of 2 stenoses. * Informed consent from patient. Exclusion Criteria: * No informed consent from the patient. * Complicated stenosis with abscess, fistula or significant activity associated with CD not limited to the area of the stenosis. * Patients with known stenosis previously treated with stenting and/or dilation performed \< 1 year before the date of inclusion. * Pregnancy or lactation. * Any clinical situation that prevents the performance of endoscopy or surgery. * Stenosis not accessible by endoscopy. * Asymptomatic patient. * Stenosis length ≥ 10 cm. * Presents with \> 2 stenoses. * Severe coagulation disorders (platelets \< 70000; INR \> 1.8).
💊

What it tests

  • Surgical resection
📍

Where

16 sites
Hospital Germans Trias i Pujol
Badalona, Spain
Hospital Universitario de Bellvitge
L'Hospitalet de Llobregat, Spain
Althaia, xarxa assistencial universitaria de Manresa
Manresa, Spain
Consorci Corporació Sanitària Parc Taulí
Sabadell, Spain
Hospital Moisès Broggi
Sant Joan Despí, Spain
Hospital Mutua de Terrassa
Terrassa, Spain
Hospital Universitario de Cáceres
Cáceres, Spain
Clínica Girona
Girona, Spain

…and 8 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy