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Inflammatory Mediators of Glaucoma After Corneal Transplantation (AH-Tears)

RecruitingNAAges 18 Years - anyAllCentre hospitalier de l'Université de Montréal (C…
NCT04339907 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Glaucoma is the most common threat to vision rehabilitation in patients with Boston keratoprosthesis type 1 (KPro) implantation. High intraocular pressure (IOP) is the most important risk factor for glaucoma and may lead to irreversible retinal and optic nerve damage. Glaucoma drainage device (GDD) surgery is used to divert aqueous humor (AH) from the anterior chamber to an external reservoir to regulate flow and decrease the IOP. The AH is in direct communication with any corneal damage or surgery undertaken in the anterior chamber and can serve as a source of potential biomarkers to detect early inflammatory or glaucomatous changes. Tears are also one of the most accessible and non-invasive source of biomarkers, especially in Kpro eyes where the central optic allows communication between aqueous humor and the tears at the surface of the eye. The investigators propose to test the hypoth

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📋 Eligibility rules (as published)
Inclusion Criteria: * Aged 18 years old or older * Informed consent * Ability to be followed for the duration of the study * Presence of ocular disease specified for each group Specific criteria for each group: * Group 1 : have no glaucoma and no systemic diseases * Group 2 : need to have glaucoma filtration surgery without prior corneal transplantation * Group 3 : need to have corneal transplantation (penetrating keratoplasty or Boston keratoprosthesis), with or without glaucoma * Group 4 : need to have intraocular surgery after prior corneal transplantation (penetrating keratoplasty or Boston keratoprosthesis) * Group 5 : need to have glaucoma filtration surgery with prior corneal transplantation (penetrating keratoplasty or Boston keratoprosthesis) Exclusion Criteria: * Aged less than 18 * Inability to give informed consent * Presence of ocular diseases other than those studied herein
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What it tests

  • Sampling of tears
  • Sampling of aqueous humor
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Where

1 site
Centre Hospitalier de l'Université de Montréal (CHUM)
Montreal, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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