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Acute Heart Failure With Reduced Ejection Fraction - COngestion Discharge Evaluation

RecruitingNAAges 18 Years - anyAllCentral Hospital, Nancy, France
NCT04343443 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The AHF-CODE reduced study is a prospective, non-randomized, monocenter study performed in patients with heart failure with reduced ejection fraction admitted for worsening heart failure. The main objective of the AHF-CODE study is to identify congestion markers (clinical, biological and ultrasound) at the end of hospitalization for acute heart failure that are associated with the risk of all cause death or rehospitalization for acute heart failure within 3 months of hospital discharge.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients hospitalised for acute heart failure. * Patients with reduced ejection fraction (Ejection Fraction \<40%) or (40% ≤ Ejection Fraction \< 50) * Patients considered clinically discharging from hospitalisation for acute heart failure. * Age ≥18 years * Patients having received complete information regarding the study design and having signed their informed consent form. * Patient affiliated to or beneficiary of a social security scheme. Exclusion Criteria: * Comorbidity for which the life expectancy is ≤ 3 months * Dialysis patient (peritoneal dialysis or hemodialysis) or patients with glomerular filtration rate \<15 ml/min/m2 at inclusion. * History of lobectomy or pneumonectomy lung surgery * Severe pulmonary or pleural pathology preventing reliable acquisition of lung ultrasound images: severe emphysema, chronic pleurisy, pulmonary fibrosis, etc. * Pregnant woman, parturient or nursing mother * Adult person subject to a legal protection measure (guardianship, curatorship, safeguard of justice) Adult person who is unable to give consent * Person deprived of liberty by a judicial or administrative decision, * Person subject to psychiatric care pursuant to Articles L. 3212-1 and L. 3213-1 of the Public Health Code.
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What it tests

  • Clinical examination centered on congestion
  • Cardio-pulmonary, peritoneal, jugular and renal Doppler ultrasounds and liver elastography
  • Biological: Blood sample retrieved for biological assessment and biobanking
  • Telephone interview
  • Kansas City Cardiomyopathy Questionnaire (KCCQ)
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Where

1 site
CHRU de Nancy
Vandœuvre-lès-Nancy, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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