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Early Detection of Familial Hypercholesterolemia in Children

Recruitingn/aAges 2 Years - 18 YearsAllInstitut Investigacio Sanitaria Pere Virgili
NCT04370899 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Heterozigous FH is an underdiagnosed disease in the paediatric population. Its early detection, would allow us to initiate lifestyle therapeutical changes and early pharmacological therapy if necessary. This is a key fact to reduce atherosclerosis progression and cardiovascular risk in adulthood. Moreover, it will allow, detecting the first and second degree affected relatives.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Children between 2 and 18 years of age. * LDL-C level above 135 mg/dL * Previously, the pediatrician will have discarded secondary causes (hypercholesterolaemia such as hypothyroidism, nephrotic syndrome, diabetes, renal insufficiency). After confirmation that one of the parents has a genetic mutation (Lipoxip/Liponext) or clinical diagnosis (DLCN ≥ 8), the child will be studied. The progenitor with hypercholesterolemia will be considered as an index case, in this way we will demonstrate the vertical transmission of the genetic disease. Exclusion Criteria: * The child population under 2 and over the age of 18 and children. * Children with high cholesterol but by secondary causes.
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What it tests

  • lifestyle assessment
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Where

2 sites
Hospital Universitari Sant Joan de Reus
Reus, Spain
Hospital Universitari Sant Joan
Reus, Spain
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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