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Novel Pulmonary Function Measures for Diagnosis of Bronchiolitis Obliterans Syndrome Following Hematopoietic Stem-Cell Transplantation in Children

Recruitingn/aAges 6 Years - 18 YearsAllThe Hospital for Sick Children
NCT04391335 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

In this study, we will study 129Xe-MRI and LCI as tools for diagnosis of BOS in pediatric patients who have received Hematopoietic Stem Cell Transplantation (HSCT) and have been identified as eligible for this study. Participants will be required to have vital signs collected, complete breathing tests and complete an MRI. The MRI will require participants to perform breath holds in the MRI scanner with xenon gas while being coached by a research assistant.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Male and female participants aged 6 -17.9 years old. * Received HSCT treatment at least 6 months prior to enrollment in study. * Participants should have an FEV1%pred value greater than 40%. * Participant understands the study procedures and is willing to participate in the study as indicated by signature on the informed consent or assent. * Participant must be able to perform a breath hold for 16s. * Participant meets MRI screening criteria Exclusion Criteria: * Participant has had a cold or respiratory infection in the last four weeks. * Participant requires supplemental oxygen or has a daytime room air oxygen saturation ≤ 95%. * Participant is unable to perform spirometry or plethysmography maneuvers. * Participant is pregnant or lactating.
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What it tests

  • Not listed
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Where

1 site
The Hospital for Sick Children
Toronto, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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