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Bern Birth Cohort / Trajectory of Microbiota Maturation in Healthy Bern Infants - a Network Approach

Recruitingn/aAges 18 Years - 45 YearsFemaleInsel Gruppe AG, University Hospital Bern
NCT04447742 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Background: Intestinal microbiota composition is fundamental to human health and undergoes critical changes within the first two years of life. Factors probably influencing the microbiota are the maternal microbiota and the general environment in Switzerland. However, the development of the intestinal microbiota is incompletely understood. Gaining knowledge of the trajectory of microbiota maturation is likely key to the understanding of the pathogenesis of many pathologies in childhood. Aims: The investigators aim for a deep understanding of the maturation of the healthy infant intestinal microbiota regarding composition, diversity and metabolic activities. The investigators aim for identifying parameters affecting microbiota maturation and effects of the microbiota on infant outcome. Methods: The investigators will recruit 250 pregnant mothers who will be followed as mother-baby pairs

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📋 Eligibility rules (as published)
Inclusion Criteria: * Signed informed consent. * Ability to understand and follow study procedures and understand informed consent * From week 20 of pregnancy until birth * General good health, i.e. absence of major severe medical/ surgical/ psychiatric condition requiring ongoing management. Minor well controlled conditions (e.g. medically controlled arterial hypertension, occupational asthma, gestational diabetes mellitus) may be present. * Absence of known severe embryonal pathology, expected normal pregnancy (e.g. minor conditions including twin/ triplet pregnancy, final pelvic position may be present) * Age 18-45 years. Exclusion Criteria: • Participation in another clinical study interfering with study procedures.
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What it tests

  • Not listed
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Where

1 site
University Hospital of Bern - Insel Spital
Bern, Switzerland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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