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Type 1 Diabetes, Endothelin, and Skeletal Muscle Mitochondrial Dysfunction: The Role of Sirtuin-1

RecruitingEARLY Phase 1Ages 18 Years - anyAllAugusta University
NCT04449198 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The proposed study is designed to test the hypothesis that treatment of resveratrol for 12 weeks will improve both endothelin-B receptor (aim 1) and skeletal muscle mitochondrial function (aim 2) in people with type 1 diabetes.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Men and premenopausal women * All races * Clinical diagnosis of insulin-dependent type 1 diabetes (patients only) Exclusion Criteria: * Clinical diagnosis of hepatic, cardiovascular, or renal disease * Uncontrolled diabetes (HbA1C \>12%) * Diabetic complications (i.e. neuropathy) * Uncontrolled hypertension (\>140/90 mm Hg on therapy) * Pregnancy * Use of vasoactive medications
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What it tests

  • Resveratrol
  • Placebo
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Where

1 site
Augusta University/Georgia Prevention Institute/ Laboratory of Integrative and Exercise Physiology
Augusta, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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