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Prostate Cancer Screening for People at Genetic Risk for Aggressive Disease, PATROL Study

Recruitingn/aAges 40 Years - anyMaleUniversity of Washington
NCT04472338 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study investigates ways to detect prostate cancer earlier in people at genetic risk for disease that forms, grows, or spreads quickly (aggressive). Studying samples of blood, urine, and/or tissue in the laboratory may help doctors further understand the genetics of prostate cancer and help identify ways to detect cancer earlier, thereby improving treatment and methods of early detection in the future.

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📋 Eligibility rules (as published)
Inclusion Criteria: * People with prostates ≥40 years of age * Documented germline pathogenic variant in known or suspected genes associated with prostate cancer risk. Exclusion Criteria: * Prior diagnosis of prostate cancer * Medical contraindication to any of the study procedures (e.g., prostate biopsy) * For all cancer types except non-melanoma skin cancer, any cancer treatment with curative intent within the past 12 months (e.g., surgery, radiation, chemotherapy, immunotherapy) * Prior or concurrent participation in an interventional clinical trial aimed at preventing cancer for people with germline variants associated with increased prostate cancer risk * Unable to provide written informed consent * Unable or unwilling to complete clinical care and study procedures as indicated by the study protocol.
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What it tests

  • Biospecimen Collection
  • Laboratory Biomarker Analysis
  • Quality-of-Life Assessment
  • Questionnaire Administration
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Where

8 sites
City of Hope
Duarte, United States
University of California, San Francisco
San Francisco, United States
Northwestern
Chicago, United States
Massachusetts General Hospital
Boston, United States
OHSU Knight Cancer Institute
Portland, United States
University of Pennsylvania/Abramson Cancer Center
Philadelphia, United States
University of Texas Health Science Center at San Antonio
San Antonio, United States
Fred Hutch/University of Washington Cancer Consortium
Seattle, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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