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โ† Trials
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Low Dose Rosuvastatin Plus Ezetimibe Versus High-dose Rosuvastatin in AMI

RecruitingPhase 4Ages 19 Years - anyAllKiyuk Chang, MD,PhD
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In plain words

What the trial is, and whether it could suit you

Combination therapy of rosuvastatin 5mg and ezetimibe 10 mg showed similar achievement rate in decreasing LDL cholesterol level by 50% as single use of rosuvastatin 20 mg. This trial aims to prove non-inferiority of concomitant usage of low dose rosuvastatin and ezetimibe among patients with acute myocardial infarction who went through percutaneous coronary intervention at decreasing major adverse cardiac events compared to the efficacy of single use of high dose rosuvastatin.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: 1. Adults Aged 19 and up 2. Patients diagnosed with myocardial infarction (both ST segment elevation and non-ST segment elevation) who were treated with percutaneous coronary intervention (Myocardial infarction defined as in the 4th Universal Definition of Myocardial Infarction) 3. For female patients who are of childbearing age, subjects that agreed on taking mandatory pregnancy test 4. Patients who agreed and signed on the informed consent form Exclusion Criteria: 1. Patients with life expectancy of a year or less due to malignancy 2. Patients with chronic liver disease 3. Patients with sensitivity to active ingredient of the research drugs (ezetimibe and/or rosuvastatin) or patients who are prohibited to take ezetimibe and/or rosuvastatin. 4. Pregnant and/or breastfeeding 5. Female patients who are unable to use any means of contraception 6. Patients receiving hemodialysis, peritoneal dialysis patients and/or kidney transplant patients, due to end stage renal disease 7. Patients who participated in other clinical trial(s) within 3 months from the screening (except non-interventional observational study) 8. Patients considered inappropriate for the study for any other reason(s) by the inspector(s)
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What it tests

  • Ezetimibe 10mg + Rosuvastatin 5mg
  • Rosuvastatin 20mg
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Where

7 sites
Bucheon St.Mary Hospital
Bucheon-si, South Korea
St.Vincent's Hospital
Suwon, South Korea
Uijeongbu St.Mary's Hospital
Uijeongbu-si, South Korea
Daejeon St.Mary's Hospital
Daejeon, South Korea
Incheon St.Mary's Hospital
Incheon, South Korea
Seoul St.Mary's Hospital
Seoul, South Korea
Yeouido St.Mary Hospital
Seoul, South Korea
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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