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Real Time Molecular Analysis of Breast Cancer Receiving Neo-adjuvant Chemotherapy

Recruitingn/aAges 18 Years - anyFemaleInstitut Paoli-Calmettes
NCT04504747 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The present project aims at identifying robust candidates for drug resistance in BC patients eligible for NAC. Its originality lies upon the combination of three different and complementary prospective approaches: from the molecular analyses of biopsies sampled before and after NAC, from in vitro BC Patient-Derived Organoids (PDO) mimicking patient's response to NAC, and from Circulating Tumor Cells (CTCs) isolated before/during/after NAC.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Woman over 18 2. Signed consent to participate 3. Invasive mammary adenocarcinoma proven histologically and / or cytologically 4. Indication of CNA retention by the referring clinical team. 5. No contraindication to CNA. 6. Selected indication of the post-CNA surgery sequence, then radiotherapy 7. Performance index ≤ 1 (WHO). 8. Affiliation to a social security scheme, or beneficiary of such a scheme Exclusion Criteria: 1. Planned therapeutic sequence: CNA, followed by neoadjuvant radiotherapy (HIST-RIC clinical trial for example) before surgery 2. Metastatic disease at diagnosis 3. Patient relapsed from breast cancer precede 4. Other malignant disease in the previous 3 years, with the exception of cervical carcinoma in situ or skin basal cell carcinoma and any other cancerous pathology considered to have been properly treated and at low risk of relapse. 5. Woman pregnant or likely to be (without effective contraception) or breastfeeding 6. Person in an emergency situation, adult person subject to a legal protection measure (adult under guardianship, guardianship or legal protection), or unable to express consent. 7. Inability to undergo medical monitoring of the trial for geographical, social or psychological reasons
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What it tests

  • molecular analysis of blood and tumor
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Where

1 site
Institut Paoli-Calmettes
Marseille, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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