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Total Intravenous Anesthesia and Recurrence Free Survival

RecruitingPhase 3Ages 18 Years - 90 YearsAllThe Cleveland Clinic
NCT04513808 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The investigators propose to compare recurrence-free survival in patients having potentially curative (Stages 1-3) surgery for esophageal cancer who will be randomly assigned to propofol-based total intravenous anesthesia or sevoflurane-based balanced general anesthesia.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Primary esophageal cancer without known extension beyond the esophagus. (i.e. believed to be Tumor Stage 1-3). * Scheduled for potentially curative esophageal cancer surgery. * Written informed consent, including willingness to be randomized to intravenous versus volatile anesthesia. Exclusion Criteria: * Previous surgery for esophageal cancer (except diagnostic biopsies) Age \<18 or \>85 years old. * ASA Physical Status ≥4. * Any contraindication to propofol or sevoflurane. * Other cancer not believed by the attending surgeon to be in long-term remission. * Systemic disease believed by the attending surgeon to present ≥25% two- year mortality.
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What it tests

  • Propofol-based total intravenous anesthesia
  • Sevoflurane intravenous anesthesia
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Where

1 site
Shanhai Chest Hospital
Shanghai, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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