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Dumping Syndrome and Esophageal Atresia

RecruitingNAAges 2 Months - 3 MonthsAllUniversity Hospital, Lille
NCT04522193 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Dumping syndrome (DS) is frequent in oesophageal atresia (29%). In causing hypoglycaemia, it can be dangerous for neonates. Mechanisms of DS are actually partialy understood. This is also an affection difficult to diagnose, because it only occurs after meals and can be inconstantly present. To date, their is only symptomatic treatment for DS. This study aims to understand its pathological mechanisms so as to better treat it and avoid its consequences. Oesophageal atresia patients enrolled in this study will benefit from a continuous glycemic monitoring, a continuous cardiac monitoring, and an a gastric emptying scintigraphy at the age of 3 months

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients operated at birth for Oesophageal atresia type C * Aged from 2 to 3 months at inclusion * Off prokinetic treatment (suspended for at least 72 hours) before monitoring Exclusion Criteria: * History of dumping syndrome of other cause (microgastria, fundoplication, dysautonomia..) * History of any disease that can modify glycemic regulation (hyperinsulinism, neonatal diabete) * Treatment that can modify gastric motility
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What it tests

  • Glycemic Holter
  • gastric emptying scintigraphy
  • Holter ECG
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Where

2 sites
Hôpital Jeanne de Flandres
Lille, France
Hôpital Jeanne de Flandre - Pôle enfant, CHU de Lille
Lille, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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