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Trajectory of Neuroinflammatory Markers in Cerebrospinal Fluid Prior to and After Thoracic Aortic Surgery

Recruitingn/aAges 18 Years - anyAllRadboud University Medical Center
NCT04523909 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Observational prospective pilot study to analyze the trajectory of neuroinflammatory protein expression in cerebrospinal fluid (CSF) in relation to systemic compartment in patients undergoing thoracic aortic surgery. The aim of this study is to identify and unravel the biochemical (neuroinflammatory) pathways involved in postoperative delirium. Patient undergoing thoracic aortic surgery will have an external lumbar drain (ELD) in situ on the day before surgery. This ELD remains in place during and three days after surgery to reduce the risk on periprocedural spinal cord ischemia. Paired measurements of CSF and blood will be analyzed.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Competent patients ≥ 18 years * Patients who will undergo thoracic aortic surgery and will therefore receive an external lumbar drain as a standard of care procedure. Exclusion Criteria: * Patients with meningitis/encephalitis/brain abscess within the last 6 months * Patients with other neurological conditions: brain injury (acute stroke, brain trauma or cerebral haemorrhage) within the last 3 months, known brain tumours, neurodegenerative disease or known pre-existing cognitive impairment (to a degree that would be compatible with mild cognitive impairment or more). * Brain or spinal surgery within the last 3 months * Active infection \<2 weeks before surgery * Patients who object against storage of their body material for scientific reasons
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What it tests

  • Trajectory of neuroinflammatory proteins in CSF and blood
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Where

1 site
Department of Intensive Care Medicine, Radboud university medical center
Nijmegen, Netherlands
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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