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Prediction of Inspiratory Effort Response to High PEEP in Patients Recovering From ARDS

Recruitingn/aAges 18 Years - anyAllSanatorio Anchorena San Martin
NCT04524091 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Spontaneous breathing during the transition from controlled to assisted ventilation in ARDS may be harmful, as high respiratory drive can generate large transpulmonary pressure swings and worsen lung injury. Higher PEEP may mitigate this by reducing inspiratory effort and lung stress, but patient response is variable and difficult to predict. While improved lung compliance appears to mediate the protective effects of PEEP, its bedside assessment is complex. Preclinical data suggest that changes in compliance are inversely reflected by changes in respiratory rate, but this relationship and its clinical utility in ARDS patients remain unclear.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Need of invasive mechanical ventilation * Patients who had fulfill ARDS criteria based on Berlin definition during any time of invasive mechanical ventilation. * Patient ventilated in pressure support ventilation. * Time of invasive ventilation expected to be longer than 24 hs after the day of enrollment. Exclusion Criteria: * Neuromuscular diseases (e.g., amyotrophic lateral sclerosis, Duchenne Erb) * previous diagnosis of chronic obstructed pulmonary disease * not resolved pneumothorax * bronchopleural fistula * suspicion of central respiratory drive alteration (e.g., benzodiazepines intoxication).
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What it tests

  • Positive end expiratory pressure
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Where

1 site
Sanatorio Anchorena de San Martin
San Martín, Argentina
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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